TY  - JOUR
PY  - 1976//
TI  - p-Chloroamphetamine: short and long term effects upon shock-elicited aggression
JO  - European journal of pharmacology
A1  - Sheard, M. H.
A1  - Davis, M.
SP  - 295
EP  - 302
VL  - 40
IS  - 2
N2  - In a series of experiments the effects of p-chloroamphetamine (PCA) on shock-elicited aggression in rats were investigated. 15 min after 5 mg/kg PCA, shock elicited aggression was inhibited. 2 h to 4 weeks after PCA, fighting was facilitated. Both the inhibitory and the excitatory effects of PCA were directly related to the dose of PCA (1.5, 2.5 OR 5 mg/kg) and were blocked by pretreatment with p-chlorophenylalanine but not by alpha-methyl-p-tyrosine. PCA-increased pain thresholds 15 min after injection and then decreased pain thresholds over the next 24 h but not thereafter, even though shock-elicited aggression continued to be facilitated. The results are consistent with the idea that inhibition of shock-elicited aggression is associated with enhanced release of serotonin whereas enhancement of shock-elicited aggression is associated with serotonin depletion.<p /> <p>Language: en</p>
LA  - en
SN  - 0014-2999
UR  - http://dx.doi.org/
ID  - ref1
ER  -