TY  - JOUR
PY  - 2013//
TI  - Sleep-dependent Neurophysiological Processes in Implicit Sequence Learning
JO  - Journal of cognitive neuroscience
A1  - Urbain, Charline
A1  - Schmitz, Rémy
A1  - Schmidt, Christina
A1  - Cleeremans, Axel
A1  - Van Bogaert, Patrick
A1  - Maquet, Pierre
A1  - Peigneux, Philippe
SP  - 2003
EP  - 2014
VL  - 25
IS  - 11
N2  - : Behavioral studies have cast doubts about the role that posttraining sleep may play in the consolidation of implicit sequence learning. Here, we used event-related fMRI to test the hypothesis that sleep-dependent functional reorganization would take place in the underlying neural circuits even in the possible absence of obvious behavioral changes. Twenty-four healthy human adults were scanned at Day 1 and then at Day 4 during an implicit probabilistic serial RT task. They either slept normally (RS) or were sleep-deprived on the first posttraining night. Unknown to them, the sequential structure of the material was based on a probabilistic finite-state grammar, with 15% chance on each trial of replacing the rules-based grammatical (G) stimulus with a nongrammatical (NG) one. Results indicated a gradual differentiation across sessions between RTs (faster RTs for G than NG), together with NG-related BOLD responses reflecting sequence learning. Similar behavioral patterns were observed in RS and sleep-deprived participants at Day 4, indicating time- but not sleep-dependent consolidation of performance. Notwithstanding, we observed at Day 4 in the RS group a diminished differentiation between G- and NG-related neurophysiological responses in a set of cortical and subcortical areas previously identified as being part of the network involved in implicit sequence learning and its offline processing during sleep, indicating a sleep-dependent processing of both regular and deviant stimuli. Our results suggest the sleep-dependent development of distinct neurophysiological processes subtending consolidation of implicit motor sequence learning, even in the absence of overt behavioral differences.<p /> <p>Language: en</p>
LA  - en
SN  - 0898-929X
UR  - http://dx.doi.org/10.1162/jocn_a_00439
ID  - ref1
ER  -