TY  - JOUR
PY  - 2014//
TI  - Improved liquid chromatography-tandem mass spectrometric method for the determination of ethyl glucuronide concentrations in hair: Applications to forensic cases
JO  - International journal of legal medicine
A1  - Imbert, Laurent
A1  - Gaulier, Jean-Michel
A1  - Dulaurent, Sylvain
A1  - Morichon, Julien
A1  - Bevalot, Fabien
A1  - Izac, Paul
A1  - Lachâtre, Gérard
SP  - 53
EP  - 58
VL  - 128
IS  - 1
N2  - Ethyl glucuronide (EtG) is a direct marker of ethanol consumption, and its assay in hair is an efficient tool for chronic alcoholism diagnosis. In 2012, the Society of Hair Testing proposed a new consensus for hair concentrations interpretation, strongly advising the use of analytical methods providing a limit of quantification of less than 3 pg/mg. The present work describes the optimization and validation of a previously developed liquid chromatography-tandem mass spectrometric method in order to comply with this recommendation. The concentration range of this improved method is from 3 to 1,000 pg/mg. Some cases are then described to illustrate the usefulness of hair EtG: a forensic post-mortem case and two cases of suspension of driving licences. Finally, hair samples of some teetotallers (n = 10) have been analyzed, which allowed neither to quantitate nor to detect any trace of EtG.<p />  <p>Language: en</p>
LA  - en
SN  - 0937-9827
UR  - http://dx.doi.org/10.1007/s00414-013-0894-8
ID  - ref1
ER  -