TY - JOUR
PY - 2005//
TI - Establishment of a canine model of severe smoke inhalation injury on unilateral lung
JO - Zhonghua Shao Shang Za Zhi
A1 - Nie, Fa-chuan
A1 - Yang, Zong-cheng
A1 - Li, Xiao-Hui
A1 - Liu, Zhi-yuan
A1 - Luo, Qi-zhi
A1 - Huang, Yue-Sheng
SP - 125
EP - 127
VL - 21
IS - 2
N2 - OBJECTIVE: To establish a canine model of severe smoke inhalation injury on unilateral lung, in order to observe the pathomorphological changes in the injured lung within 24 postburn hours (PBHs). METHODS: Twenty five mongrel dogs were employed in the study and randomized into 3 groups. The left lung was injured by inhaling smoke produced by burning sawdust with sparing the right lung with a breathing tube in 10 dogs in group A. A conventional model of smoke inhalation injury to bilateral lungs was reproduced in 8 dogs in group B, and dogs in group C not subjected to smoke inhalation served as controls. Hemodynamic changes, blood gas analysis and the pathophysiologic changes in the lungs were observed within 24 PBHs. RESULTS: All of the dogs in groups A and C survived. Hemodynamic indices in the dogs in groups A and C remained stable without showing signs of systemic hypoxia. The arterial oxygen partial pressure in dogs of group A was 65 +/- 5 mm Hg, and the oxygen saturation in the mixed blood was 0.64 +/- 0.04 at 24 PBHs, and they were much lower than those in group C but higher than those in group B. The pathological changes in the injured side of the lungs in group A were similar to those in group B with high consistency, and the changes, though milder, could also be identified in the contralateral uninjured lung. Five dogs died in the group B within 24 hours after smoke inhalation and the survivors showed signs of multiple organ failure. CONCLUSION: The canine model of acute severe unilateral pulmonary smoke inhalation injury was reproduced reliably, and could be an ideal model for the study on smoke inhalation injury. Language: zh
LA - zh
SN - 1009-2587
UR - http://dx.doi.org/
ID - ref1
ER -