TY  - JOUR
PY  - 2013//
TI  - Injury during pregnancy and nervous system birth defects: Texas, 1999 to 2003
JO  - Birth defects research. Part A, clinical and molecular teratology
A1  - Sauber-Schatz, Erin K.
A1  - Bodnar, Lisa M.
A1  - Weiss, Harold B.
A1  - Wilson, John W.
A1  - Pearlman, Mark D.
A1  - Markovic, Nina
SP  - 641
EP  - 648
VL  - 97
IS  - 10
N2  - BACKGROUND: Case reports and series have suggested an association between injury during pregnancy and several nervous system and nervous system-related adverse fetal/neonatal outcomes. This study's purpose is to further determine if there is an association between injury during pregnancy and nervous system birth defects in infancy. METHODS: Through a case-control study, the association between injury during pregnancy and nervous system birth defects was tested using the Texas Birth Defects Registry (1999-2003). Semiautomated probabilistic bias analysis was used to correct for systematic error from misclassification of injury during pregnancy. RESULTS: Of the 59,750 infants eligible for this study, 4144 (6.94%) were diagnosed with a nervous system birth defect and 315 (0.53%) of the infants' mothers were injured during pregnancy. Among these 315 women, 25 (7.94%) delivered an infant with a subsequent nervous system birth defect. The adjusted odds ratio for the association between injury during pregnancy and nervous system birth defects among all study infants was 1.00; 95% confidence interval, 0.63-1.56 and 2.44; 95% confidence interval, 1.08-5.53 among breech presentation infants. Probabilistic bias analysis supported these findings. CONCLUSION: No association between injury during pregnancy and nervous system birth defects was identified. Further exploration into the association among breech presentation infants is warranted. Birth Defects Research (Part A), 2013. © 2013 Wiley Periodicals, Inc.<p />  <p>Language: en</p>
LA  - en
SN  - 1542-0752
UR  - http://dx.doi.org/10.1002/bdra.23143
ID  - ref1
ER  -