TY  - JOUR
PY  - 2014//
TI  - fMRI response during figural memory task performance in college drinkers
JO  - Psychopharmacology
A1  - Dager, Alecia D.
A1  - Jamadar, Sharna
A1  - Stevens, Michael C.
A1  - Rosen, Rivkah
A1  - Jiantonio-Kelly, Rachel E.
A1  - Sisante, Jason-Flor
A1  - Raskin, Sarah A.
A1  - Tennen, Howard
A1  - Austad, Carol S.
A1  - Wood, Rebecca M.
A1  - Fallahi, Carolyn R.
A1  - Pearlson, Godfrey D.
SP  - 167
EP  - 179
VL  - 231
IS  - 1
N2  - RATIONALE: Eighteen- to twenty-five-year-olds show the highest rates of alcohol use disorders (AUD) and heavy drinking, which may have critical neurocognitive implications. Regions subserving memory may be particularly susceptible to alcohol-related impairments. OBJECTIVE: We used blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to examine the neural correlates of visual encoding and recognition among heavy-drinking college students. We predicted that heavy drinkers would show worse memory performance, increased frontal/parietal activation, and decreased hippocampal response during encoding. METHODS: Participants were 23 heavy drinkers and 33 demographically matched light drinkers, aged 18-20, characterized using quantity/frequency of drinking and AUD diagnosis. Participants performed a figural encoding and recognition task during fMRI. BOLD response during encoding was modeled based on whether each stimulus was subsequently recognized or forgotten (i.e., correct vs. incorrect encoding). RESULTS: There were no group differences in behavioral performance. Compared to light drinkers, heavy drinkers showed (1) greater BOLD response during correct encoding in the right hippocampus/medial temporal, right dorsolateral prefrontal, left inferior frontal, and bilateral posterior parietal cortices; (2) less left inferior frontal activation and greater bilateral precuneus deactivation during incorrect encoding; and (3) less bilateral insula response during correct recognition (clusters >10,233 μl, p < 0.05 whole brain). CONCLUSIONS: This is the first investigation of the neural substrates of figural memory among heavy-drinking older adolescents. Heavy drinkers demonstrated compensatory hyperactivation of memory-related areas during correct encoding, greater deactivation of default mode regions during incorrect encoding, and reduced recognition-related response. Results could suggest use of different encoding and recognition strategies among heavy drinkers.<p />  <p>Language: en</p>
LA  - en
SN  - 0033-3158
UR  - http://dx.doi.org/10.1007/s00213-013-3219-1
ID  - ref1
ER  -