TY  - JOUR
PY  - 2013//
TI  - Changes in intrinsic functional brain networks following blast-induced mild traumatic brain injury
JO  - Brain injury
A1  - Vakhtin, Andrei A.
A1  - Calhoun, Vince D.
A1  - Jung, Rex E.
A1  - Prestopnik, Jillian L.
A1  - Taylor, Paul A.
A1  - Ford, Corey C.
SP  - 1304
EP  - 1310
VL  - 27
IS  - 11
N2  - OBJECTIVE: Blast-induced mild traumatic brain injuries (mTBI) commonly go undetected by computed tomography and conventional magnetic resonance imaging (MRI). This study was used to investigate functional brain network abnormalities in a group of blast-induced mTBI subjects using independent component analysis (ICA) of resting state functional MRI (fMRI) data. METHODS: Twenty-eight resting state networks of 13 veterans who sustained blast-induced mTBI were compared with healthy controls across three fMRI domains: blood oxygenation level-dependent spatial maps, time course spectra and functional connectivity. RESULTS: The mTBI group exhibited hyperactivity in the temporo-parietal junctions and hypoactivity in the left inferior temporal gyrus. Abnormal frequencies in default-mode (DMN), sensorimotor, attentional and frontal networks were detected. In addition, functional connectivity was disrupted in six network pairs: DMN-basal ganglia, attention-sensorimotor, frontal-DMN, attention-sensorimotor, attention-frontal and sensorimotor-sensorimotor. CONCLUSIONS: The results suggest white matter disruption across certain attentional networks. Additionally, given their elevated activity relative to controls', the temporo-parietal junctions of blast mTBI subjects may be compensating for diffuse axonal injury in other cortical regions.<p />  <p>Language: en</p>
LA  - en
SN  - 0269-9052
UR  - http://dx.doi.org/10.3109/02699052.2013.823561
ID  - ref1
ER  -