TY  - JOUR
PY  - 2013//
TI  - Beta-cathinone derivatives--a new generation of dangerous psychostimulant "designer drugs"
JO  - Przeglad Lekarski
A1  - Zawilska, Jolanta B.
A1  - Słomiak, Krzysztof
A1  - Wasiak, Mateusz
A1  - Woźniak, Patrycja
A1  - Massalski, Michał
A1  - Krupa, Emilia
A1  - Wojcieszak, Jakub Ł
SP  - 386
EP  - 391
VL  - 70
IS  - 6
N2  - Synthetic beta-cathinone derivatives belong to the novel group of psychostimulant "designer drugs". They show significant structural similarity to catecholamines and exogenous central nervous system (CNS) stimulating agents such as amphetamine, methamphetamine, ephedrine, 3,4-methylenedioxy-N-methylamphetamine (MDMA, ecstasy), and act as dopamine, noradrenaline and serotonin reuptake inhibitors. Popular synthetic beta-cathinones include e.g. mephedrone (4-methylmethcathinone, 4-MMC), naphyrone (naphthylpyrovalerone) and MDPV (3,4-methylenedioxypyrovalerone). Ingestion of synthetic cathinones produces effects of CNS stimulation, often comparable to those evoked by cocaine, amphetamine and MDMA. Chronic abuse of beta-cathinone derivatives leads to the development of tolerance, psychic and physical dependence. This paper discusses pharmacological properties of the most commonly used beta-cathinone derivatives as well as risks associated with their abuse. Special emphasis is given to neurological, psychiatric, cardiovascular and hematologic disturbances. Authors also present cases of fatalities caused by acute beta-cathinone intoxication or resulting from the drug-related accidents and crimes.<p />  <p>Language: pl</p>
LA  - pl
SN  - 0033-2240
UR  - http://dx.doi.org/
ID  - ref1
ER  -