TY  - JOUR
PY  - 2013//
TI  - Medication and suicide risk in schizophrenia: A nested case-control study
JO  - Schizophrenia Research
A1  - Reutfors, Johan
A1  - Bahmanyar, Shahram
A1  - Jonsson, Erik G.
A1  - Brandt, Lena
A1  - Bodén, Robert
A1  - Ekbom, Anders
A1  - Osby, Urban
SP  - 416
EP  - 420
VL  - 150
IS  - 2-3
N2  - INTRODUCTION: Patients with schizophrenia are at increased risk of suicide, but data from controlled studies of pharmacotherapy in relation to suicide risk is limited. AIM: To explore suicide risk in schizophrenia in relation to medication with antipsychotics, antidepressants, and lithium. METHODS: Of all patients with a first clinical discharge diagnosis of schizophrenia or schizoaffective disorder in Stockholm County between 1984 and 2000 (n=4000), patients who died by suicide within five years from diagnosis were defined as cases (n=84; 54% male). Individually matched controls were identified from the same population. Information on prescribed medication was retrieved from psychiatric records in a blinded way. Adjusted odds ratios [OR] of the association between medication and suicide were calculated by conditional logistic regression. RESULTS: Lower suicide risk was found in patients who had been prescribed a second generation antipsychotic (clozapine, olanzapine, risperidone, or ziprasidone; 12 cases and 20 controls): OR 0.29 (95% confidence interval [CI], 0.09-0.97). When the 6 cases and 8 controls who had been prescribed clozapine were excluded, the OR was 0.23 (95% CI 0.06-0.89). No significant association was observed between suicide and prescription of any antipsychotic, depot injection antipsychotics, antidepressants, SSRI, or lithium. CONCLUSIONS: Lower suicide risk for patients who had been prescribed second generation antipsychotics may be related to a pharmacological effect of these drugs, to differences in adherence, or to differences in other patient characteristics associated with lower suicide risk.<p />  <p>Language: en</p>
LA  - en
SN  - 0920-9964
UR  - http://dx.doi.org/10.1016/j.schres.2013.09.001
ID  - ref1
ER  -