TY - JOUR PY - 2014// TI - Haplotype analysis of the DISC1 Ser704Cys variant in Japanese suicide completers JO - Psychiatry research A1 - Ratta-Apha, Woraphat A1 - Hishimoto, Akitoyo A1 - Mouri, Kentaro A1 - Shiroiwa, Kyoichi A1 - Sasada, Toru A1 - Yoshida, Masakuni A1 - Okazaki, Satoshi A1 - Supriyanto, Irwan A1 - Asano, Migiwa A1 - Ueno, Yasuhiro A1 - Shirakawa, Osamu A1 - Sora, Ichiro SP - 249 EP - 251 VL - 215 IS - 1 N2 - The present study investigated the genetic association of the disrupted-in-schizophrenia 1 (DISC1) gene with suicide using 398 Japanese completed suicides and 511 healthy controls. The functional Ser704Cys variant of DISC1 was nominally associated with completed suicide. Enhanced evidence of association was observed in a multi-marker sliding window haplotype analysis (the lowest p=0.002). These findings warrant further studies with a larger sample size to confirm the association of DISC1 with suicide.

Language: en

LA - en SN - 0165-1781 UR - http://dx.doi.org/10.1016/j.psychres.2013.11.007 ID - ref1 ER -