TY  - JOUR
PY  - 2014//
TI  - Racial Susceptibility for QT Prolongation in Acute Drug Overdoses
JO  - Journal of electrocardiology
A1  - Manini, Alex F.
A1  - Stimmel, Barry
A1  - Vlahov, David
SP  - 244
EP  - 250
VL  - 47
IS  - 2
N2  - BACKGROUND AND PURPOSE: QT prolongation independently predicts adverse cardiovascular events in suspected poisoning. We aimed to evaluate the association between race and drug-induced QT prolongation for patients with acute overdose. METHODS: This was a cross-sectional observational study at two urban teaching hospitals. Consecutive adult ED patients with acute drug overdose were prospectively enrolled over a two year period. The primary outcome, long-QT, was defined using standard criteria: QTc>470ms in females and>460ms in males. The association between race and drug-induced QT prolongation was tested, considering several confounding variables. RESULTS: In 472 patients analyzed (46% female, mean age 42.3), QT prolongation occurred in 12.7%. Blacks had two-fold increased odds of drug-induced QT prolongation (OR 2.01, CI 1.03-3.91) and Hispanics had 48% decreased odds of drug-induced QT prolongation (OR 0.52, CI 0.29-0.94). CONCLUSIONS: We found significant racial susceptibility to drug-induced QT prolongation in this large urban study of acute overdoses.<p /> <p>Language: en</p>
LA  - en
SN  - 0022-0736
UR  - http://dx.doi.org/10.1016/j.jelectrocard.2013.12.002
ID  - ref1
ER  -