TY  - JOUR
PY  - 2014//
TI  - Neurobiological mechanisms for impulsive-aggression: The role of MAOA
JO  - Current topics in behavioral neurosciences
A1  - Dorfman, Hayley M.
A1  - Meyer-Lindenberg, Andreas
A1  - Buckholtz, Joshua W.
SP  - 297
EP  - 313
VL  - 17
IS  - 
N2  - Aggression may be present across a large part of the spectrum of psychopathology, and underlies costly criminal antisocial behaviors. Human aggression is a complex and underspecified construct, confounding scientific discovery. Nevertheless, some biologically tractable subtypes are apparent, and one in particular-impulsive (reactive) aggression-appears to account for many facets of aggression-related dysfunction in psychiatric illness. Impulsive-aggression is significantly heritable, suggesting genetic transmission. However, the specific neurobiological mechanisms that mediate genetic risk for impulsive-aggression remain unclear. Here, we review extant data on the genetics and neurobiology of individual differences in impulsive-aggression, with particular attention to the role of genetic variation in Monoamine Oxidase A (MAOA) and its impact on serotonergic signaling within corticolimbic circuitry.<p />  <p>Language: en</p>
LA  - en
SN  - 1866-3370
UR  - http://dx.doi.org/10.1007/7854_2013_272
ID  - ref1
ER  -