TY  - JOUR
PY  - 1992//
TI  - Cimetidine-induced fatality: Confirmation by HPLC-MS
JO  - Journal (Canadian Society of Forensic Science)
A1  - Alpe-Scott, M. D.
A1  - Lindsay, D.
SP  - 91
EP  - 96
VL  - 25
IS  - 2
N2  - Cimetidine, an histamine H2-receptor antagonist, used primarily in the treatment of various gastric disorders, has only been documented twice as the toxic agent in instances of fatal overdosage. A case is presented involving the suicidal death of a middle-aged woman. Routine toxicological analysis revealed therapeutic blood concentrations of diazepam, nordiazepam and Phenytoin with a large peak at carbon number 1930 unidentified by gas chromatography-mass spectrometry (GC-MS). Cimetidine was confirmed by high performance liquid chromatrography-mass spectrometry (HPLC-MS) analysis. Isocratic ion-pairing reversed phase HPLC was used to quantify Cimetidine and the following results obtained: blood (780 μg/mL), urine (19000/μg/mL), liver (20000 μg/g) and gastric contents (9.5 g of Cimetidine in 170 g).<p />
LA  - en
SN  - 0008-5030
UR  - http://dx.doi.org/10.1080/00085030.1992.10757004
ID  - ref1
ER  -