TY  - JOUR
PY  - 2014//
TI  - Sleep duration and depressive symptoms: A gene-environment interaction
JO  - Sleep
A1  - Watson, Nathaniel F.
A1  - Harden, Kathryn Paige
A1  - Buchwald, Dedra
A1  - Vitiello, Michael V.
A1  - Pack, Allan I.
A1  - Strachan, Eric
A1  - Goldberg, Jack
SP  - 351
EP  - 358
VL  - 37
IS  - 2
N2  - OBJECTIVE: We used quantitative genetic models to assess whether sleep duration modifies genetic and environmental influences on depressive symptoms. METHOD: Participants were 1,788 adult twins from 894 same-sex twin pairs (192 male and 412 female monozygotic [MZ] pairs, and 81 male and 209 female dizygotic [DZ] pairs] from the University of Washington Twin Registry. Participants self-reported habitual sleep duration and depressive symptoms. Data were analyzed using quantitative genetic interaction models, which allowed the magnitude of additive genetic, shared environmental, and non-shared environmental influences on depressive symptoms to vary with sleep duration. RESULTS: Within MZ twin pairs, the twin who reported longer sleep duration reported fewer depressive symptoms (ec = -0.17, SE = 0.06, P < 0.05). There was a significant gene × sleep duration interaction effect on depressive symptoms (a'c = 0.23, SE = 0.08, P < 0.05), with the interaction occurring on genetic influences that are common to both sleep duration and depressive symptoms. Among individuals with sleep duration within the normal range (7-8.9 h/night), the total heritability (h(2)) of depressive symptoms was approximately 27%. However, among individuals with sleep duration within the low (< 7 h/night) or high (≥ 9 h/night) range, increased genetic influence on depressive symptoms was observed, particularly at sleep duration extremes (5 h/night: h(2) = 53%; 10 h/night: h(2) = 49%). CONCLUSION: Genetic contributions to depressive symptoms increase at both short and long sleep durations. CITATION: Watson NF; Harden KP; Buchwald D; Vitiello MV; Pack AI; Stachan E; Goldberg J. Sleep duration and depressive symptoms: a gene-environment interaction. SLEEP 2014;37(2):351-358.<p />  <p>Language: en</p>
LA  - en
SN  - 0161-8105
UR  - http://dx.doi.org/10.5665/sleep.3412
ID  - ref1
ER  -