TY  - JOUR
PY  - 2014//
TI  - Posttraumatic epilepsy - Disease or comorbidity?
JO  - Epilepsy and behavior
A1  - Pitkänen, Asla
A1  - Kemppainen, Samuli
A1  - Ndode-Ekane, Xavier Ekolle
A1  - Huusko, Noora
A1  - Huttunen, Joanna K.
A1  - Gröhn, Olli
A1  - Immonen, Riikka
A1  - Sierra, Alejandra
A1  - Bolkvadze, Tamuna
SP  - 19
EP  - 24
VL  - 38
IS  - 
N2  - Traumatic brain injury (TBI) can cause a myriad of sequelae depending on its type, severity, and location of injured structures. These can include mood disorders, posttraumatic stress disorder and other anxiety disorders, personality disorders, aggressive disorders, cognitive changes, chronic pain, sleep problems, motor or sensory impairments, endocrine dysfunction, gastrointestinal disturbances, increased risk of infections, pulmonary disturbances, parkinsonism, posttraumatic epilepsy, or their combinations. The progression of individual pathologies leading to a given phenotype is variable, and some progress for months. Consequently, the different post-TBI phenotypes appear within different time windows. In parallel with morbidogenesis, spontaneous recovery occurs both in experimental models and in human TBI. A great challenge remains; how can we dissect the specific mechanisms that lead to the different endophenotypes, such as posttraumatic epileptogenesis, in order to identify treatment approaches that would not compromise recovery? This article is part of a Special Issue entitled "NEWroscience 2013".<p /> <p>Language: en</p>
LA  - en
SN  - 1525-5050
UR  - http://dx.doi.org/10.1016/j.yebeh.2014.01.013
ID  - ref1
ER  -