TY  - JOUR
PY  - 2014//
TI  - Associations between interhemispheric functional connectivity and the Automated Neuropsychological Assessment Metrics (ANAM) in civilian mild TBI
JO  - Brain imaging and behavior
A1  - Sours, Chandler
A1  - Rosenberg, Joseph
A1  - Kane, Richard
A1  - Roys, Steven R.
A1  - Zhuo, Jiachen
A1  - Shanmuganathan, Kathirkamanthan
A1  - Gullapalli, Rao P.
SP  - 190
EP  - 203
VL  - 9
IS  - 2
N2  - This study investigates cognitive deficits and alterations in resting state functional connectivity in civilian mild traumatic brain injury (mTBI) participants with high and low symptoms. Forty-one mTBI participants completed a resting state fMRI scan and the Automated Neuropsychological Assessment Metrics (ANAM) during initial testing (<10 days of injury) and a 1 month follow up. Data were compared to 30 healthy control subjects. Results from the ANAM demonstrate that mTBI participants performed significantly worse than controls on the code substitution delayed subtest (p = 0.032) and weighted throughput score (p = 0.001). Among the mTBI patients, high symptom mTBI participants performed worse than those with low symptoms on the code substitution delayed (p = 0.017), code substitution (p = 0.012), repeated simple reaction time (p = 0.031), and weighted throughput score (p = 0.009). Imaging results reveal that during the initial visit, low symptom mTBI participants had reduced interhemispheric functional connectivity (IH-FC) within the lateral parietal lobe (p = 0.020); however, during follow up, high symptom mTBI participants showed reduced IH-FC compared to the control group within the dorsolateral prefrontal cortex (DLPFC) (p = 0.013). Reduced IH-FC within the DLPFC during the follow-up was associated with reduced cognitive performance. Together, these findings suggest that reduced rs-FC may contribute to the subtle cognitive deficits noted in high symptom mTBI participants compared to control subjects and low symptom mTBI participants.<p />  <p>Language: en</p>
LA  - en
SN  - 1931-7557
UR  - http://dx.doi.org/10.1007/s11682-014-9295-y
ID  - ref1
ER  -