TY  - JOUR
PY  - 2014//
TI  - Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer
JO  - Acta neuropathologica communications
A1  - Ling, Helen
A1  - Kara, Eleanna
A1  - Revesz, Tamas
A1  - Lees, Andrew J.
A1  - Plant, Gordon T.
A1  - Martino, Davide
A1  - Houlden, Henry
A1  - Hardy, John
A1  - Holton, Janice L.
SP  - 24
EP  - 24
VL  - 2
IS  - 1
N2  - We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60's followed by memory impairment, low mood and recurrent falls. Examination shortly before death revealed hypomimia, dysarthria, vertical supranuclear gaze palsy and impaired postural reflexes. Pathological examination demonstrated 4-repeat tau neuronal and glial lesions, including tufted astrocytes, consistent with a diagnosis of progressive supranuclear palsy. In addition, neurofibrillary tangles composed of mixed 3-repeat and 4-repeat tau and astrocytic tangles in a distribution highly suggestive of chronic traumatic encephalopathy were observed together with limbic TDP-43 pathology. Possible mechanisms for the co-occurrence of these two tau pathologies are discussed.<p />  <p>Language: en</p>
LA  - en
SN  - 2051-5960
UR  - http://dx.doi.org/10.1186/2051-5960-2-24
ID  - ref1
ER  -