TY  - JOUR
PY  - 2012//
TI  - Differential effects of diazepam, tandospirone, and paroxetine on plasma brain-derived neurotrophic factor level under mental stress
JO  - Human psychopharmacology
A1  - Tamaji, Ai
A1  - Iwamoto, Kunihiro
A1  - Kawamura, Yukiko
A1  - Takahashi, Masahiro
A1  - Ebe, Kazutoshi
A1  - Kawano, Naoko
A1  - Kunimoto, Shohko
A1  - Aleksic, Branko
A1  - Noda, Yukihiro
A1  - Ozaki, Norio
SP  - 329
EP  - 333
VL  - 27
IS  - 3
N2  - OBJECTIVES: Serum brain-derived neurotrophic factor (BDNF) levels are reduced in depressed patients, and successful antidepressant treatment leads to increases in BDNF levels. However, little is known about how psychotropic drugs affect the mechanism of the human response to mental stress. We investigated the influence of psychotropic drugs on plasma BDNF levels under mental stress using a driving simulator (DS) task. METHODS: Fourteen healthy male volunteers received one of four drugs, diazepam (5 mg), tandospirone (20 mg), paroxetine (10 mg), and matched placebo, in a double-blind, crossover manner. Subjects were asked to perform the DS task 4 h post-dosing. Plasma BDNF levels were measured before and after the DS task. RESULTS: Plasma BDNF levels under the placebo, diazepam, and tandospirone conditions significantly decreased after the DS task compared with before the task. Conversely, no significant differences in plasma BDNF levels were detected under the paroxetine condition. CONCLUSION: As these three psychotropic drugs have differential effects on plasma BDNF levels under mental stress after 4 h post-dosing, antidepressants, unlike anxiolytics, might have a prompt positive effect on the mental stress response.<p /> <p>Language: en</p>
LA  - en
SN  - 0885-6222
UR  - http://dx.doi.org/10.1002/hup.2220
ID  - ref1
ER  -