TY  - JOUR
PY  - 2013//
TI  - The effect of trazodone on standardized field sobriety tests
JO  - Pharmacotherapy
A1  - Ip, Eric J.
A1  - Bui, Quang V.
A1  - Barnett, Mitchell J.
A1  - Kazani, Amin
A1  - Wright, Roger
A1  - Serino, Melissa J.
A1  - Perry, Paul J.
SP  - 369
EP  - 374
VL  - 33
IS  - 4
N2  - STUDY OBJECTIVE: To evaluate the effects of a single dose of trazodone on the standardized field sobriety test (SFST). DESIGN: A randomized, double-blinded, repeated-measures study. PARTICIPANTS: Forty-five healthy adult subjects. SETTING: University campus. MEASUREMENTS AND MAIN RESULTS: The SFST consists of the horizontal gaze nystagmus, walk-and-turn, and one-leg stand tests. Subjects were administered a baseline SFST and at 2 hours after the administration of either trazodone 100 mg (30 subjects) or acetaminophen 650 mg (15 subjects). At 2 hours post drug administration, there were no statistical differences in failure rates between the trazodone and acetaminophen groups (53.3% vs 20.0%, p=0.054). However, the trazodone group exhibited more impairment clues within the individual tests of the SFST than the acetaminophen group. CONCLUSIONS: A one-time dose of trazodone 100 mg does not result in an increased SFST failure rate at 2 hours postdosing compared to acetaminophen 650 mg. However, the number of individual impairment clues detected is increased with trazodone. Trazodone 100 mg may cause cognitive driving impairment.<p />  <p>Language: en</p>
LA  - en
SN  - 0277-0008
UR  - http://dx.doi.org/10.1002/phar.1210
ID  - ref1
ER  -