TY  - JOUR
PY  - 1978//
TI  - Central therapeutic effects of dihydroderivative of pralidoxime (pro-2-PAM) in organophosphate intoxication
JO  - Archives Internationales de Pharmacodynamie et de Therapie
A1  - Rump, S.
A1  - Faff, J.
A1  - Borkowska, G.
A1  - Ilczuk, I.
A1  - Rabsztyn, T.
SP  - 321
EP  - 332
VL  - 232
IS  - 2
N2  - Central actions of pro-2-PAM (dihydroderivative of 2-PAM) and 2-PAM in poisonings with DFP have been studied. It was shown that pro-2-PAM significantly increased activity of DFP inhibited acetylcholinesterase in the brain, quickly ceased the DFP-induced paralysis of respiration, partially normalized the DFP-induced abnormalities in electrocorticogram and increased the convulsive dosis of DFP. Effects of 2-PAM in these experiments were negligible.<p /> <p>Language: en</p>
LA  - en
SN  - 0003-9780
UR  - http://dx.doi.org/
ID  - ref1
ER  -