TY  - JOUR
PY  - 2014//
TI  - Linked sex differences in cognition and functional connectivity in youth
JO  - Cerebral cortex
A1  - Satterthwaite, Theodore D.
A1  - Wolf, Daniel H.
A1  - Roalf, David R.
A1  - Ruparel, Kosha
A1  - Erus, Guray
A1  - Vandekar, Simon
A1  - Gennatas, Efstathios D.
A1  - Elliott, Mark A.
A1  - Smith, Alex
A1  - Hakonarson, Hakon
A1  - Verma, Ragini
A1  - Davatzikos, Christos
A1  - Gur, Raquel E.
A1  - Gur, Ruben C.
SP  - 2383
EP  - 2394
VL  - 25
IS  - 9
N2  - Sex differences in human cognition are marked, but little is known regarding their neural origins. Here, in a sample of 674 human participants ages 9-22, we demonstrate that sex differences in cognitive profiles are related to multivariate patterns of resting-state functional connectivity MRI (rsfc-MRI). Males outperformed females on motor and spatial cognitive tasks; females were faster in tasks of emotion identification and nonverbal reasoning. Sex differences were also prominent in the rsfc-MRI data at multiple scales of analysis, with males displaying more between-module connectivity, while females demonstrated more within-module connectivity. Multivariate pattern analysis using support vector machines classified subject sex on the basis of their cognitive profile with 63% accuracy (P < 0.001), but was more accurate using functional connectivity data (71% accuracy; P < 0.001). Moreover, the degree to which a given participant's cognitive profile was "male" or "female" was significantly related to the masculinity or femininity of their pattern of brain connectivity (P = 2.3 × 10(-7)). This relationship was present even when considering males and female separately. Taken together, these results demonstrate for the first time that sex differences in patterns of cognition are in part represented on a neural level through divergent patterns of brain connectivity.<p />  <p>Language: en</p>
LA  - en
SN  - 1047-3211
UR  - http://dx.doi.org/10.1093/cercor/bhu036
ID  - ref1
ER  -