TY  - JOUR
PY  - 2014//
TI  - Female gender and acne disease are jointly and independently associated with the risk of major depression and suicide: a national population-based study
JO  - BioMed research international
A1  - Yang, Yi-Chien
A1  - Tu, Hung-Pin
A1  - Hong, Chien-Hui
A1  - Chang, Wei-Chao
A1  - Fu, Hung-Chun
A1  - Ho, Ji-Chen
A1  - Chang, Wei-Pin
A1  - Chuang, Hung-Yi
A1  - Lee, Chih-Hung
SP  - e504279
EP  - e504279
VL  - 2014
IS  - 
N2  - Acne is a common disease in adolescence with female preponderance. It could cause poor self-esteem and social phobia. Previous studies based on questionnaires from several thousands of adolescents showed that acne is associated with major depression and suicide. However, the gender- and age-specific risk of depression and suicide in patients with acne remain largely unknown. Using a database from the National Health Insurance, which included 98% of the population of Taiwan in 2006, we identified patients of acne, major depression, and suicide based on ICD-9-CM codes. Totally 47111 patients with acne were identified (16568 males and 30543 females) from 1 million subjects. The youths of 7-12 years had the highest prevalence of acne (14.39%). Major depression was more common in those with acne (0.77%) than controls (0.56% , P < 0.0001) regardless of gender. Multiple logistic regression showed an increased risk of major depression in women without acne (OR = 1.85, 95% CI 1.75-1.96). The risk is additive in women with acne (OR = 2.78, 95% CI 2.43-3.17). Similar additive risk of suicide was noticed in women with acne. In conclusion, acne and gender, independently and jointly, are associated with major depression and suicide. Special medical support should be warranted in females with acne for the risk of major depression and suicide.<p />  <p>Language: en</p>
LA  - en
SN  - 2314-6133
UR  - http://dx.doi.org/10.1155/2014/504279
ID  - ref1
ER  -