TY  - JOUR
PY  - 1978//
TI  - Ethanol: modifications of acute intoxication by divalent cations
JO  - Science
A1  - Erickson, C. K.
A1  - Tyler, T. D.
A1  - Harris, R. A.
SP  - 1219
EP  - 1221
VL  - 199
IS  - 4334
N2  - Calcium, other divalent cations, and calcium antagonists were tested for their ability to alter ethanol-induced sleeping time, hypothermia, and behavioral intoxication in mice and rats. Calcium given intraventricularly significantly enhanced sleeping time and behavioral intoxication in a dose-related manner. The ionophores X537A and A23187 accentuated the effect of a low dose of calcium, whereas the calcium chelators EDTA and EGTA decreased sleeping time. Calcium also enhanced tertiary butanol- and chloral hydrate-induced sleeping time. The effects of cations on ethanol-induced hypothermia were less significant. The results suggest the existence of a central calcium pool that is involved in ethanol intoxication in rodents.<p /> <p>Language: en</p>
LA  - en
SN  - 0036-8075
UR  - http://dx.doi.org/
ID  - ref1
ER  -