TY  - JOUR
PY  - 2014//
TI  - Cytotoxicity studies of semi-synthetic derivatives of theveside derived from the aqueous extract of leaves of 'suicide tree' Cerbera odollam
JO  - Natural product research
A1  - Gorantla, Jaggaiah N.
A1  - Vellekkatt, Jamsheena
A1  - Nath, Lekshmi R.
A1  - Anto, Ruby John
A1  - Lankalapalli, Ravi S.
SP  - 1507
EP  - 1512
VL  - 28
IS  - 18
N2  - We report the isolation of two known iridoid glucosides theviridoside (1) and theveside (2) from the aqueous extract of leaves of Cerbera odollam and semi-synthetic derivatisation of theveside prepared in a single step under protection group-free conditions. Derivatives 2a-j were evaluated for cytotoxicity towards five human cancer cell lines of different origins, namely SKBR3 (breast), HeLa (cervical), A375 (skin), HepG2 (liver) and HCT-116 (colon), and IC50 values were determined. Derivatives 2b and 2h exhibited moderate cytotoxicity against HCT-116 and A375 cell lines, respectively.<p />  <p>Language: en</p>
LA  - en
SN  - 1478-6419
UR  - http://dx.doi.org/10.1080/14786419.2014.913242
ID  - ref1
ER  -