TY  - JOUR
PY  - 2001//
TI  - Activation of thalamo-cortical systems in post-traumatic flashbacks: a positron emission tomography study
JO  - Traumatology
A1  - Huber, Michael
A1  - Siol, Torsten
A1  - Herholz, Karl
A1  - Lenz, Olaf
A1  - Köhle, Karl
A1  - Heiss, Wolf Dieter
SP  - 131
EP  - 141
VL  - 7
IS  - 4
N2  - Trauma victims with post-traumatic stress disorder (PTSD) often experience 'flashbacks' that are described as being different from memories of other fearful biographic situations. We used Positron Emission Tomography and Statistical Parametric Mapping to compare in the same subject brain activation patterns during induced flashbacks with recall of fearful non-traumatic situations. During fearful recall there were significant activations of right precuneus. When traumatic memories were compared to neutral, right lingual gyrus, right thalamus / mamillary bodies, and right cerebellum were significantly activated. When brain activation during flashbacks was compared to simple fear, right mediodorsal thalamus (MD), right precuneus, and right cerebellum were significantly more active. With respect to recent experimental evidence concerning the function of thalamo-cortical systems, we hypothesize that post-traumatic flashback experiences are based on hyperactive thalamo-cortical 'closed loop' networks.<p /> <p>Language: en</p>
LA  - en
SN  - 1534-7656
UR  - http://dx.doi.org/10.1177/153476560100700402
ID  - ref1
ER  -