TY  - JOUR
PY  - 2014//
TI  - Drug- and herb-induced liver injury: A case series from a single center
JO  - Turkish journal of gastroenterology : the Official Journal of Turkish Society of Gastroenterology
A1  - Dağ, Muhammed Said
A1  - Aydınlı, Musa
A1  - Oztürk, Zeynel Abidin
A1  - Türkbeyler, Ibrahim Halil
A1  - Koruk, Irfan
A1  - Savaş, Muhammed Cemil
A1  - Koruk, Mehmet
A1  - Kadayıfçı, Abdurrahman
SP  - 41
EP  - 45
VL  - 25
IS  - 1
N2  - BACKGROUND/AIMS: Drug-induced liver injury (DILI) is common worldwide and has a potentially fatal outcome. It accounts for more than half of the cases of acute liver failure in the United States. Herb-induced liver injury (HILI) is a less documented condition but a growing problem. We present here the clinical characteristics and outcome of patients with drug- and herb-induced liver injury from our center. <br><br>MATERIALS AND METHODS: In this 4-year retrospective study, 82 patients in whom there was a causal or highly probable relationship between herbal medicine or drug use and liver disease are presented. <br><br>RESULTS: The mean age of patients was 43.1±14.8 years; sexual distribution was 53 females and 29 males. The major cause of hepatotoxicity was drugs (87.8%), with herbal medicine accounting for 12.2%. The leading causative agents were nonsteroidal anti-inflammatory drugs (NSAIDs) (23.1%), followed by antibiotics (19.5%). The pattern of hepatotoxicity was hepatocellular in 35 patients (42.6%), mixed in 28 (34.1%), and cholestatic in 19 patients (23.1%). Teucrium polium (known popularly as felty germander), which is a traditionally used herbal medicine of the Labiatae family in our region, was the most common cause of herb-induced liver injury and responsible in 7 of 10 herbal hepatotoxic cases. Acute liver failure developed in 3 patients (two patients related with flurbiprofen and diclofenac and one patient due to an isoniazid-rifampicin combination). <br><br>CONCLUSION: Antibiotics and NSAIDs were the most common etiologic agents for drug-induced liver injury. Surprisingly, herbs follow these groups of drugs and must be questioned more carefully.<p />  <p>Language: en</p>
LA  - en
SN  - 1300-4948
UR  - http://dx.doi.org/10.5152/tjg.2014.4486
ID  - ref1
ER  -