TY  - JOUR
PY  - 2010//
TI  - Does clozapine promote employability and reduce offending among mentally disordered offenders?
JO  - Canadian journal of psychiatry, The
A1  - Balbuena, Lloyd
A1  - Mela, Mansfield
A1  - Wong, Stephen
A1  - Gu, Deqiang
A1  - Adelugba, Olajide O.
A1  - Tempier, Raymond
SP  - 50
EP  - 56
VL  - 55
IS  - 1
N2  - OBJECTIVE: To compare employment pay, count of infractions, and clinical symptoms in psychiatric inmates treated with clozapine or other antipsychotics after 6 months of treatment. <br><br>METHODS: Clinical charts and institutional offence records of psychiatric inmates (n = 98), comprised of those on clozapine (n = 65) and on other antipsychotics (n = 33), were reviewed at baseline and after 6 months of treatment. The outcome measures used were Brief Psychiatric Rating Scale (BPRS) scores, employment pay, medication compliance, and the frequency of institutional offences. A binary logistic regression model was used to analyze a categorical change in pay variable, while a negative binomial model was used to analyze the frequency of infractions. <br><br>RESULTS: Treatment with clozapine was associated with greater odds of a pay increase (OR = 3.13; 95% CI 1.3 to 7.53, P = 0.01). However, patients on other antipsychotics had a more favourable improvement in BPRS (F = 5.44, df = 1,57, P = 0.02). Patients on other antipsychotics also had a higher count of posttreatment offences (Incidence Rate Ratio = 2.22; 95% CI 1.11 to 4.41, P = 0.02). <br><br>CONCLUSION: Clozapine probably has a favourable effect on inmate behaviour and institutional adjustment. This effect can last up to 36 months after the initial dose.<p /> <p>Language: en</p>
LA  - en
SN  - 0706-7437
UR  - http://dx.doi.org/
ID  - ref1
ER  -