TY  - JOUR
PY  - 2014//
TI  - Significant head accelerations can influence immediate neurological impairments in a murine model of blast-induced traumatic brain injury
JO  - Journal of biomechanical engineering
A1  - Gullotti, David M.
A1  - Panzer, Matthew B.
A1  - Beamer, Matthew
A1  - Chen, Yung Chia
A1  - Patel, Tapan P.
A1  - Yu, Allen
A1  - Jaumard, Nicolas
A1  - Winkelstein, Beth
A1  - Bass, Cameron R.
A1  - Morrison, Barclay
A1  - Meaney, David F.
SP  - 091004
EP  - 091004
VL  - 136
IS  - 9
N2  - Although blast-induced traumatic brain injury (bTBI) is well recognized for its significance in the military population, the unique mechanisms of primary bTBI remain undefined. Animate models of primary bTBI are critical for determining these potentially unique mechanisms, but the biomechanical characteristics of many bTBI models are poorly understood. In this study, we examine some common shock tube configurations used to study blast-induced brain injury in the laboratory, and define the optimal configuration to minimize the effect of torso overpressure and blast-induced head accelerations. Pressure transducers indicated that a customized animal holder successfully reduced peak torso overpressures to safe levels across all tested configurations. However, high-speed video imaging acquired during the blast showed significant head accelerations occurred when animals were oriented perpendicular to the shock tube axis. Under the same blast input conditions, minimizing head acceleration led to a corresponding elimination of righting time deficits. However, we could still achieve righting time deficits under minimal acceleration conditions by significantly increasing the peak blast overpressure. Together, these data show the importance of characterizing the effect of blast overpressure on head kinematics, with the goal of producing models focused on understanding the effects of blast overpressure on the brain without the complicating factor of superimposed head accelerations. KEYWORDS Blast, traumatic brain injury, biomechanics, acceleration, overpressure.<p />  <p>Language: en</p>
LA  - en
SN  - 0148-0731
UR  - http://dx.doi.org/10.1115/1.4027873
ID  - ref1
ER  -