TY - JOUR PY - 1979// TI - Protective effects of a novel thromboxane analog in lethal traumatic shock JO - Prostaglandins Med A1 - Lefer, A. M. A1 - Araki, H. A1 - Smith, J. B. A1 - Nicolaou, K. C. A1 - Magolda, R. L. SP - 139 EP - 146 VL - 3 IS - 3 N2 - Pinane thromboxane A2 (PTA2) an analog of thromboxane A2 that inhibits the formation of thromboxanes as well as antagonizes their biological actions, at an infusion rate of 1.0 mumole. kg-1. h-1, prolonged survival in traumatic shock in rats. PTA2 also prevented the accumulation of thromboxane B2, the lysosomal protease, cathepsin D, and the cardiotoxic peptide MDF in the circulating blood.

Language: en

LA - en SN - 0161-4630 UR - http://dx.doi.org/ ID - ref1 ER -