TY  - JOUR
PY  - 2002//
TI  - Pharmacokinetic simulation of plasma concentrations of (Delta)9-tetrahydrocannabinol (THC) after oral ingestion of hemp oil
JO  - Blutalkohol
A1  - Toennes, Stefan W.
A1  - Kauert, Gerold F.
SP  - 237
EP  - 243
VL  - 39
IS  - 4
N2  - The BgVV introduced guidelines for (Delta)9-tetrahydrocannabinol. (THC) concentration in food containing hemp. With regard to potentially measurable concentrations in blood, there may be complications with the (section)24a, sec 2 StVG (German traffic law). A simulation model was established from literature data on pharmacokinetics, which was then applied to the oral ingestion of THC from hemp oil with the highest permissible value (5000 (mu)g/kg). The parmacokinetic simulation was carried out using the Excel programme AutoKinetic. 20% was taken as bio-availability, 0.23h as the absorption half-life, 3.23 1/kg as volume of the central compartment, 3.85 h as distribution half-life and 25 h as the terminal elimination half life. The simulation estimate of the maximum plasma concentration of THC after oral ingestion of 40 g of hemp oil containing 0.2 mg THC by a person weighing 50 kg was 0.21 (mu)g/1. This value lies within the range of the detection limit and below the quantification limit of modern highly sensitive analytical methods. Therefore it cannot be assumed that measurable plasma concentrations of THC might result following the ingestion of food containing hemp, which would fulfil the guidelines introduced by the BgVV.    Keywords: Cannabis impaired driving  <p />
LA  - de
SN  - 0006-5250
UR  - http://dx.doi.org/
ID  - ref1
ER  -