TY  - JOUR
PY  - 1987//
TI  - The ethics of randomized clinical trials
JO  - American journal of medicine
A1  - Rosner, F.
SP  - 283
EP  - 290
VL  - 82
IS  - 2
N2  - Randomized clinical trials pose a number of fundamental ethical problems to which morally sensitive investigators must give careful consideration. The randomized double-blind clinical trial is ethically justified and the preferred method of demonstrating therapeutic effectiveness and safety. Alternate methods such as crossover and self-controlled designs, the use of historical controls, observational methods, and practitioner's clinical trials also exist and have their place in certain circumstances. The use of randomized double-blind clinical trials must assure adequate explanation of the research plan to the patient, the documentation of informed consent, adequate consideration of safety, and an acceptably low risk/benefit ratio.<p /> <p>Language: en</p>
LA  - en
SN  - 0002-9343
UR  - http://dx.doi.org/
ID  - ref1
ER  -