TY  - JOUR
PY  - 1988//
TI  - Biphasic effects of alcohol drinking on methamphetamine metabolism in man
JO  - Alcohol and alcoholism
A1  - Shimosato, K.
A1  - Oda, H.
A1  - Ohmae, M.
A1  - Tomita, M.
A1  - Doi, Y.
SP  - 351
EP  - 357
VL  - 23
IS  - 5
N2  - In methamphetamine (MAP) addicts, long-term ethanol ingestion 3-4 times per week induced an increased rate of p-hydroxylation of MAP and amphetamine (AMP). Simultaneous ingestion of ethanol and MAP inhibited both p-hydroxylation of MAP and AMP and N-demethylation of MAP in inebriated addicts. The p-hydroxylation of MAP and AMP was also significantly inhibited in daily drinkers despite the almost total absence of urinary ethanol. This suggests that the intensity of MAP-induced behavioral and psychological effects in MAP addicts may, in part, depend upon their drinking habits.<p /> <p>Language: en</p>
LA  - en
SN  - 0735-0414
UR  - http://dx.doi.org/
ID  - ref1
ER  -