TY  - JOUR
PY  - 2014//
TI  - Existing and novel biological therapeutics in suicide prevention
JO  - American journal of preventive medicine
A1  - Griffiths, Joshua J.
A1  - Zarate, Carlos A.
A1  - Rasimas, J. J.
SP  - S195
EP  - S203
VL  - 47
IS  - Suppl
N2  - We summarize outcomes for several pharmacologic and neurostimulatory approaches that have been considered potential treatments to reduce suicide risk, namely, by reducing suicide deaths, attempts, and ideation in various clinical populations. Available treatments include clozapine, lithium, antidepressants, antipsychotics, electroconvulsive therapy, and transcranial magnetic stimulation. The novel repurposing of ketamine as a potential suicide risk-mitigating agent in the acute setting is also discussed. Research pathways to better understand and treat suicidal ideation and behavior from a neurobiological perspective are proposed in light of this foundation of information and the limitations and challenges inherent in suicide research. Such pathways include trials of fast-acting medications, registry approaches to identify appropriate patients for trials, identification of biomarkers, neuropsychological vulnerabilities, and endophenotypes through the study of known suicide risk-mitigating agents in hope of determining mechanisms of pathophysiology and the action of protective biological interventions.<p />  <p>Language: en</p>
LA  - en
SN  - 0749-3797
UR  - http://dx.doi.org/10.1016/j.amepre.2014.06.012
ID  - ref1
ER  -