TY  - JOUR
PY  - 2014//
TI  - Familial factors associated with development of alcohol and mental health comorbidity
JO  - Addiction
A1  - Salom, C. L.
A1  - Williams, G. M.
A1  - Najman, J. M.
A1  - Alati, R.
SP  - 248
EP  - 257
VL  - 110
IS  - 2
N2  - BACKGROUND AND AIM: Co-occurring mental health and alcohol problems appear to be associated with greater health burdens than either single disorder. This study compares familial and individual contributions to development of comorbid alcohol/mental problems and tests whether these differ from single disorders. <br><br>DESIGN: Women (n=6703) were recruited during pregnancy to the longitudinal Mater-University of Queensland Study of Pregnancy (MUSP). Mother/offspring dyads were followed over 21 years. SETTING: Mater-Misericordiae Public Hospital, Brisbane, Australia. PARTICIPANTS: Primary offspring from the MUSP with full psychiatric information at 21 years and maternal information at 14 (n=1755). MEASUREMENTS: Structured interviews at 21 yielded a four-category outcome using mental health and alcohol modules of the Composite International Diagnostic Interview [no disorder, alcohol only, mental health only, and comorbid alcohol/mental health]. Multinomial logistic regression models were adjusted for gender, maternal mental health and substance use, family environment and adolescent behaviour. <br><br>FINDINGS: Maternal smoking (OR=1.56; CI95 =1.09-2.22 vs no-disorder) and low mother-offspring warmth (OR=3.19; CI95 =1.99-5.13) were associated with mental health/alcohol comorbidity in young adults, as were adolescent drinking (OR=2.22; CI95 =1.25-3.96), smoking (OR=2.24; CI95 =1.33-3.77) and attention/thought problems (OR=2.04; CI95 =1.18-3.52). Some differences were seen from single disorders. In a sub-sample with paternal data, fathers' drinking problems (OR=2.41; CI95 =1.10-5.29) were more strongly associated with offspring mental health/alcohol comorbidity than both single disorders (p<0.05). <br><br>CONCLUSIONS: Maternal smoking and low mother-child warmth appear to be related to alcohol, mental health and comorbid disorders at age 21, possibly via constituent alcohol and mental health disorders. Adolescent drinking and attention/thought problems appear to be associated with comorbid disorders but not with individual alcohol and mental health disorders.<p />  <p>Language: en</p>
LA  - en
SN  - 0965-2140
UR  - http://dx.doi.org/10.1111/add.12722
ID  - ref1
ER  -