TY  - JOUR
PY  - 1988//
TI  - Paracetamol poisoning in a swine model
JO  - Z Exp Chir Transplant Kunstliche Organe
A1  - Henne-Bruns, D.
A1  - Artwohl, J.
A1  - Dziwisch, L.
A1  - Kremer, B.
SP  - 255
EP  - 263
VL  - 21
IS  - 5
N2  - In order to prove the function of isolated transplanted hepatocytes in acute liver failure we tried to establish a hepatic failure model in pigs which correlates to a clinical situation. In 12 pigs we administered 500-2000 mg/kg body weight acetaminophen after enzyme induction with Pentobarbital. 7 animals receiving 500-1000 mg/kg acetaminophen survived the intoxication, 5 animals receiving 1000-2000 mg/kg acetaminophen died within 6.5 hours after intoxication because of methemoglobinemia. A close correlation between administered dosage of the drug, acetaminophen blood levels and methemoglobinemia was found. Histology of surviving animals showed a dosage depended cell necrosis. A standardized hepatic failure model could not be established in pigs by acetaminophen intoxication, because dosages of more than 1000 mg/kg were survived. In dosage higher than 1000 mg/kg a side effect of the acetaminophen intoxication the methemoglobinemia limited the life of the animals. Therefore acetaminophen can not be used to induce acute hepatic failure in pigs.<p /> <p>Language: de</p>
LA  - de
SN  - 0232-7295
UR  - http://dx.doi.org/
ID  - ref1
ER  -