TY  - JOUR
PY  - 2014//
TI  - Differences in subjective response to alcohol in heavy and light drinking Chinese men versus Caucasian American men
JO  - Addiction
A1  - Rueger, Sandra Yu
A1  - Hu, Hongxing
A1  - McNamara, Patrick
A1  - Cao, Dingcai
A1  - Hao, Wei
A1  - King, Andrea C.
SP  - 91
EP  - 99
VL  - 110
IS  - 1
N2  - AIMS: Compare subjective responses to alcohol among Han Chinese and Caucasian American males. <br><br>DESIGN: Double-blinded, placebo-controlled human laboratory design. Participants completed three randomized experimental sessions with high and low alcohol, and placebo beverage. SETTING: Chinese participants were examined at Xinjiang Medical University, China. Caucasian participants were examined at the University of Chicago, USA. PARTICIPANTS: 70 Han Chinese (35 heavy/35 light drinkers) and 75 Caucasian Americans (43 heavy/32 light drinkers). MEASUREMENTS: Breath alcohol concentration (BrAC) and the Stimulation and Sedation subscales of the Biphasic Alcohol Effects Scale were assessed at pre-drink baseline and four timepoints after beverage consumption. The Like and Want subscales of the Drug Effects Questionnaire were also assessed at the post-drink assessments. <br><br>FINDINGS: Comparisons with light drinkers showed that high and low dose alcohol produced decreases in stimulation, liking, and wanting in Chinese vs. Caucasians (ps<.05), and dose-dependent increases in sedation in both groups (ps<0.001). Among heavy drinkers, high dose alcohol produced higher stimulation (p<0.001) but with concomitant higher sedation for both doses (ps<0.05) for Chinese vs. Caucasians. Alcohol also demonstrated significantly lower liking (ps<0.001) in Chinese vs. Caucasian heavy drinkers for both doses. Interestingly, both groups showed dose dependent increases in wanting relative to placebo (ps<0.05), but the magnitude of the increase was lower in Chinese. <br><br>CONCLUSIONS: Stimulating effects of alcohol are predominant in Chinese male binge drinkers, as has been found-in Caucasians, but with less hedonic and motivational reward, potentially explaining some of the lower risk for alcohol disorders in Asian subgroups.<p />  <p>Language: en</p>
LA  - en
SN  - 0965-2140
UR  - http://dx.doi.org/10.1111/add.12737
ID  - ref1
ER  -