TY  - JOUR
PY  - 2014//
TI  - Re-examining premature mortality in anorexia nervosa: A meta-analysis redux
JO  - Comprehensive psychiatry
A1  - Keshaviah, Aparna
A1  - Edkins, Katherine
A1  - Hastings, Elizabeth R.
A1  - Krishna, Meera
A1  - Franko, Debra L.
A1  - Herzog, David B.
A1  - Thomas, Jennifer J.
A1  - Murray, Helen B.
A1  - Eddy, Kamryn T.
SP  - 1773
EP  - 1784
VL  - 55
IS  - 8
N2  - Anorexia nervosa (AN) is reported to have the highest premature mortality of any psychiatric disorder, but recent meta-analyses may have inflated estimates. We sought to re-estimate mortality after methodological corrections and to identify predictors of mortality. We included 41 cohorts from 40 peer-reviewed studies published between 1966 and 2010. <br><br>METHODS included double data extraction, log-linear regression with an over-dispersed Poisson model, and all-cause and suicide-specific standardized mortality ratios (SMRs), with 95% Poisson confidence intervals. Participants with AN were 5.2 [3.7-7.5] times more likely to die prematurely from any cause, and 18.1 [11.5-28.7] times more likely to die by suicide than 15-34year old females in the general population. Our estimates were 10% and 49% lower, respectively, than previously reported SMRs. Risk of premature mortality was highest in studies with older participants, although confounding by treatment was present. Gender, ascertainment, and diagnostic criteria also impacted risk.<p /> <p>Language: en</p>
LA  - en
SN  - 0010-440X
UR  - http://dx.doi.org/10.1016/j.comppsych.2014.07.017
ID  - ref1
ER  -