TY  - JOUR
PY  - 2014//
TI  - Are carbohydrate-deficient transferrin assays useful for the detection of recurrent 'binge drinking' in children with an alcohol intoxication in the emergency department?
JO  - Alcohol and alcoholism
A1  - Stokbroekx, Margot A. L.
A1  - Houterman, Saskia
A1  - Coolen, Stefan A. J.
A1  - van der Lely, Nico
A1  - Pelleboer, Rolf A. A.
SP  - 635
EP  - 638
VL  - 49
IS  - 6
N2  - AIMS: The aim of this study was to evaluate different carbohydrate-deficient transferrin (CDT) assays for the detection of recurrent excessive alcohol abuse in adolescents prior to acute alcohol intoxication. <br><br>METHODS: Data on drinking behaviour and CDT levels of adolescents (13-18 years) registered at the outpatient clinic for youth and alcohol at three major district general hospitals in the Netherlands were retrospectively collected. CDT and disialotransferrin (DST) levels of binge-drinking teenagers were compared with non-binge-drinking teenagers. <br><br>RESULTS: In total 198 samples were collected for the N Latex CDT method (N = 83), no differences were found in mean CDT levels for binge versus non-binge drinkers (P = 0.8). The Helander HPLC (N = 78) showed significantly higher values for binge drinkers than for non-binge drinkers (mean 1.20%DST, SD 0.28 and mean 1.01%DST, SD 0.31, respectively (P = 0.01)). The Recipe ClinRep method (N = 37) also showed significantly higher values for binge drinkers (mean 1.17%DST, SD 0.36 and mean 0.89%DST, SD 0.34, respectively (P = 0.03)). <br><br>CONCLUSION: With the Helander HPLC method and the Recipe ClinRep assay higher levels are measured in binge drinkers than in non-binge drinkers.<p />  <p>Language: en</p>
LA  - en
SN  - 0735-0414
UR  - http://dx.doi.org/10.1093/alcalc/agu050
ID  - ref1
ER  -