TY  - JOUR
PY  - 2014//
TI  - A predictive microsimulation model to estimate the clinical relevance of reducing alcohol consumption in alcohol dependence
JO  - European addiction research
A1  - François, Clément
A1  - Laramée, Philippe
A1  - Rahhali, Nora
A1  - Chalem, Ylana
A1  - Aballéa, Samuel
A1  - Millier, Aurélie
A1  - Bineau, Sébastien
A1  - Toumi, Mondher
A1  - Rehm, Jürgen
SP  - 269
EP  - 284
VL  - 20
IS  - 6
N2  - BACKGROUND: Alcohol consumption is one of the most important factors for disease and disability in Europe. In clinical trials, nalmefene has resulted in a significant reduction in the number of heavy-drinking days (HDDs) per month and total alcohol consumption (TAC) among alcohol-dependent patients versus placebo. <br><br>METHODS: A microsimulation model was developed to estimate alcohol-attributable diseases and injuries in patients with alcohol dependence and to explore the clinical relevance of reducing alcohol consumption. <br><br>RESULTS: For all diseases and injuries considered, the number of events (inpatient episodes) increased with the number of HDDs and TAC per year. The model predicted that a reduction of 20 HDDs per year would result in 941 fewer alcohol-attributable events per 100,000 patients, while a reduction in intake of 3,000 g/year of pure alcohol (ethanol) would result in 1,325 fewer events per 100,000 patients. <br><br>CONCLUSION: The potential gains of reducing consumption in alcohol-dependent patients were considerable. © 2014 S. Karger AG, Basel.<p />  <p>Language: en</p>
LA  - en
SN  - 1022-6877
UR  - http://dx.doi.org/10.1159/000362408
ID  - ref1
ER  -