TY  - JOUR
PY  - 2014//
TI  - Inverse association between obesity predisposing FTO genotype and completed suicide
JO  - PLoS one
A1  - Chojnicka, Izabela
A1  - Fudalej, Sylwia
A1  - Walczak, Anna
A1  - Wasilewska, Krystyna
A1  - Fudalej, Marcin
A1  - Stawiński, Piotr
A1  - Strawa, Katarzyna
A1  - Pawlak, Aleksandra
A1  - Wojnar, Marcin
A1  - Krajewski, Paweł
A1  - Płoski, Rafał
SP  - e108900
EP  - e108900
VL  - 9
IS  - 9
N2  - The A allele of rs9939609 in the FTO gene predisposes to increased body mass index (BMI) and obesity. Recently we showed an inverse association between the obesity related A allele of rs9939609 and alcohol dependence which was replicated by others. Since this finding raises a possibility that FTO may be associated with other psychiatric phenotypes, we aimed to examine association of rs9939609 with completed suicide. We genotyped rs9939609 in 912 suicide victims and 733 controls using TaqMan approach. We observed an inverse association between suicide and the rs9939609 A allele (OR = 0.80, P = 0.002, Pcor = 0.006) with genotype distribution suggesting a co-dominant effect. Given the link between alcoholism and suicide under influence of alcohol reported in Polish population, confounding by alcohol addiction was unlikely due to apparently similar effect size among cases who were under influence of ethanol at the time of death (OR = 0.76, P = 0.003, N = 361) and those who were not (OR = 0.80, P = 0.007, N = 469). The search for genotype-phenotype correlations did not show significant results. In conclusion, our study proves that there is an inverse association between rs9939609 polymorphism in FTO gene and completed suicide which is independent from association between FTO and alcohol addiction.<p />  <p>Language: en</p>
LA  - en
SN  - 1932-6203
UR  - http://dx.doi.org/10.1371/journal.pone.0108900
ID  - ref1
ER  -