TY  - JOUR
PY  - 2014//
TI  - Modulating speed-accuracy strategies in major depression
JO  - Journal of psychiatric research
A1  - Vallesi, Antonino
A1  - Canalaz, Francesca
A1  - Balestrieri, Matteo
A1  - Brambilla, Paolo
SP  - 103
EP  - 108
VL  - 60
IS  - 
N2  - BACKGROUND: Depression is associated with deficits in cognitive flexibility. The role of general slowing in modulating more specific cognitive deficits is however unclear. <br><br>AIM: We assessed how depression affects the capacity to strategically adapt behavior between harsh and prudent response modalities and how general and specific processes may contribute to performance deficits. <br><br>METHODS: Patients suffering from major depression and age- and education-matched healthy controls were asked to randomly stress either speed or accuracy during perceptual decision-making. <br><br>RESULTS: Diffusion models showed that patients with depression kept using a less conservative strategy after a trial with speed vs. accuracy instructions. Additionally, the depression group showed a slower rate of evidence accumulation as indicated by a generally lower drift rate. <br><br>CONCLUSIONS: These data demonstrate that less efficient strategic regulation of behavior in depression is due not only to general slowing, but also to more specific deficits, such as a rigid dependence on past contextual instructions. Future studies should investigate the neuro-anatomical basis of this deficit.<p /> <p>Language: en</p>
LA  - en
SN  - 0022-3956
UR  - http://dx.doi.org/10.1016/j.jpsychires.2014.09.017
ID  - ref1
ER  -