TY - JOUR PY - 1989// TI - Cerebellar degeneration in neuroleptic malignant syndrome: neuropathologic findings and review of the literature concerning heat-related nervous system injury JO - Journal of neurology, neurosurgery, and psychiatry A1 - Lee, S. A1 - Merriam, A. A1 - Kim, T. S. A1 - Liebling, M. A1 - Dickson, D. W. A1 - Moore, G. R. SP - 387 EP - 391 VL - 52 IS - 3 N2 - A selective subtotal cerebellar neuronal degeneration was found in a patient who died 4 1/2 months after suffering neuroleptic malignant syndrome (NMS), a rare, potentially fatal disorder associated with neuroleptic medications. It is suggested that the cerebellar neuronal degeneration in this case was due to hyperpyrexia, a cardinal clinical feature of NMS. Similar pathologic findings appear not to have been previously reported in NMS but have been described in heat-induced central nervous system (CNS) injury. The findings imply that a cerebellar syndrome might be encountered in patients who survive NMS complicated by a particularly high febrile course.
Language: en
LA - en SN - 0022-3050 UR - http://dx.doi.org/ ID - ref1 ER -