TY - JOUR PY - 1989// TI - Effect of carbidine on parameters of ethanol oxidation in experimental alcoholic intoxication JO - Farmakologiia i Toksikologiia A1 - Gurtovenko, V. M. A1 - Kuznetsova, N. I. A1 - Shumaĭlov, I. N. A1 - Proskuriakova, T. V. A1 - Eremina, R. V. SP - 83 EP - 86 VL - 52 IS - 3 N2 - The effect of carbidine on enzymes of ethanol and acetaldehyde oxidation, the rate of ethanol elimination and the parameters of ethanol consumption were studied during long-term alcoholic intoxication. Carbidine administration was shown to increase the activity of alcohol dehydrogenase of the liver tissue, to decrease the activity of aldehyde dehydrogenase with a low Km to acetaldehyde. Also, the rate of ethanol elimination and a relative amount of consumed ethanol increase at the expense of an increase of the volume of consumed liquid.
Language: ru
LA - ru SN - 0014-8318 UR - http://dx.doi.org/ ID - ref1 ER -