TY  - JOUR
PY  - 1989//
TI  - The role of excitatory amino acids and NMDA receptors in traumatic brain injury
JO  - Science
A1  - Faden, Alan I.
A1  - Demediuk, P.
A1  - Panter, S. S.
A1  - Vink, R.
SP  - 798
EP  - 800
VL  - 244
IS  - 4906
N2  - Brain injury induced by fluid percussion in rats caused a marked elevation in extracellular glutamate and aspartate adjacent to the trauma site. This increase in excitatory amino acids was related to the severity of the injury and was associated with a reduction in cellular bioenergetic state and intracellular free magnesium. Treatment with the noncompetitive N-methyl-D-aspartate (NMDA) antagonist dextrophan or the competitive antagonist 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid limited the resultant neurological dysfunction; dextrorphan treatment also improved the bioenergetic state after trauma and increased the intracellular free magnesium. Thus, excitatory amino acids contribute to delayed tissue damage after brain trauma; NMDA antagonists may be of benefit in treating acute head injury.<p /> <p>Language: en</p>
LA  - en
SN  - 0036-8075
UR  - http://dx.doi.org/
ID  - ref1
ER  -