TY  - JOUR
PY  - 1986//
TI  - Refinement of an EEG diurnal vigilance index. Application to drug trials
JO  - Revue D'électroencéphalographie et de Neurophysiologie Clinique
A1  - Goldenberg, F.
SP  - 39
EP  - 48
VL  - 16
IS  - 1
N2  - Theta/alpha spectral powers ratio was used to quantify physiological decrease of vigilance occurring after 5 min recording eyes closed, at different times of the day, in normal volunteers with 'high alpha'. Maximum decrease of vigilance occurred at about 2 or 4 p.m. Theta/alpha ratio fluctuations were similar on the homologous right and left scalp areas. This ratio is useful in psychopharmacology to quantify the antagonist activity of a CNS stimulant drug on the physiological decrease of vigilance after 5 min as well as the sedative effect of a drug. It allows to follow the kinetics of the drug action at receptor level.<p /> <p>Language: fr</p>
LA  - fr
SN  - 0370-4475
UR  - http://dx.doi.org/
ID  - ref1
ER  -