TY  - JOUR
PY  - 2014//
TI  - Assessment of the "case-chaos" design as an adjunct to the case-control design
JO  - American journal of epidemiology
A1  - Doerken, Sam
A1  - Mockenhaupt, Maja
A1  - Schumacher, Martin
A1  - Sekula, Peggy
SP  - 775
EP  - 780
VL  - 179
IS  - 6
N2  - In 2012, a novel case series method dubbed the "case-chaos" design was proposed as an alternative to case-control studies, whereby controls are artificially created by permutating the exposure information of the cases. Our aim in the current work was to further evaluate the case-chaos method. Using a theoretical example of 2 risk factors, we demonstrated that the case-chaos design yields risk estimations for which the odds ratios obtained for every risk factor are in the same ascending order as the risk factors' exposure prevalences in the case group. Applying the method to data from the European Study of Severe Cutaneous Adverse Reactions (EuroSCAR; 1997-2001), we were not able to obtain sensible results but instead produced results as predicted by our theoretical assessment. We therefore claim that the method is equivalent to declaring risk solely on the basis of prevalences obtained in cases. While the proposers of the case-chaos method view it as a useful adjunct, we show that it cannot produce sensible estimates.<p />  <p>Language: en</p>
LA  - en
SN  - 0002-9262
UR  - http://dx.doi.org/10.1093/aje/kwt310
ID  - ref1
ER  -