TY  - JOUR
PY  - 2014//
TI  - Inclusion of hazardous drinking does not improve the SCORE performance in men from Central and Eastern Europe: the findings from the HAPIEE cohorts
JO  - BMC public health
A1  - Vikhireva, Olga
A1  - Kubinova, Ruzena
A1  - Malyutina, Sofia
A1  - Paj K, Andrzej
A1  - Simonova, Galina
A1  - Bobak, Martin
A1  - Pikhart, Hynek
SP  - 1187
EP  - 1187
VL  - 14
IS  - 
N2  - BACKGROUND: The SCORE (Systematic COronary Risk Evaluation) scale uses conventional risk factors for the prediction of the 10-year risk of fatal atherosclerotic cardiovascular disease (CVD). The high-risk version of SCORE is recommended by the European Society of Cardiology for use in the populations of Central and Eastern Europe and former Soviet Union (CEE/FSU). Given the role of hazardous alcohol consumption as an important determinant of CVD mortality in CEE/FSU men, this study investigated whether adding hazardous drinking characteristics to the high-risk SCORE improves its prognostic performance in contemporary population-based male CEE/FSU cohorts METHODS: The HAPIEE (Health, Alcohol, and Psychosocial factors In Eastern Europe) study follows Czech (seven towns), Polish (Krakow), and Russian (Novosibirsk) cohorts from 2002-2005. In HAPIEE men (n = 8,927), 264 atherosclerotic cardiovascular deaths were registered over the median follow-up time of 6.2-8.1 years. <br><br>RESULTS: In HAPIEE men, the baseline levels of the high-risk SCORE >=5% significantly predicted fatal CVD. After controlling for the high-risk SCORE, binge drinking (drinking >=100 g of ethanol at least once a month) and problem drinking (>=2 positive answers to CAGE questionnaire) were inconsistently associated with fatal CVD. No marked improvement in calibration and discrimination was observed for the high-risk SCORE extended by these hazardous drinking indicators, and all values of integrated discrimination improvement were <0.5%. <br><br>CONCLUSIONS: Extending the high-risk SCORE by hazardous drinking parameters failed to improve its prognostic performance across male CEE/FSU population samples. Our findings tentatively support the use of the original high-risk SCORE in male CEE/FSU populations. More research is needed on the potential use of hazardous drinking in cardiovascular risk prediction.<p />  <p>Language: en</p>
LA  - en
SN  - 1471-2458
UR  - http://dx.doi.org/10.1186/1471-2458-14-1187
ID  - ref1
ER  -