TY  - JOUR
PY  - 2014//
TI  - Treatment-resistant depression: state of the art. Part I. Nosography and clinic
JO  - Rivista di psichiatria
A1  - Luchini, Federica
A1  - Cosentino, Luca
A1  - Pensabene, Laura
A1  - Mauri, Mauro
A1  - Lattanzi, Lorenzo
SP  - 207
EP  - 216
VL  - 49
IS  - 5
N2  - Aims. This work would give an overall vision of the actual knowledge about nosography and clinic of treatment-resistant depression. <br><br>METHOD. A PubMed, PsychInfo, Google Scolar search was done using the key words "resistant depression", "STAR*D", "bipolar depression", "staging". Have been selected exclusively works in English, French and Italian languages. <br><br>RESULTS. Treatment-resistant depression is one of the most important problem in public health. Nevertheless a general consensus about its definition and staging does not exist at now. Principal risk factors and associated comorbidities are well known including the association with bipolar spectrum; anyway the disease particularly common among depressed outpatients is still very disabling, responsible of an often chronic course, with numerous relapses and high risk of suicide. <br><br>DISCUSSION and conclusion. The future investigations, once improved procedures for differential diagnosis and subtyping of clinical depression, should be directed to the search of a shared definition of treatment resistance and the development of specific therapeutic protocols.<p />  <p>Language: it</p>
LA  - it
SN  - 0035-6484
UR  - http://dx.doi.org/10.1708/1668.18260
ID  - ref1
ER  -