TY  - JOUR
PY  - 2014//
TI  - Burns and epilepsy - review and case report
JO  - Burns: journal of the International Society for Burn Injuries
A1  - Gragnani, Alfredo
A1  - Müller, Bruno Rafael
A1  - Oliveira, Andrea Fernandes
A1  - Ferreira, Lydia Masako
SP  - e15
EP  - 8
VL  - 41
IS  - 2
N2  - Decompensation of epilepsy in burned patients may be caused by several factors. Burn is a classic etiology of systemic inflammatory response syndrome, and evolves into two physiological phases. The first 48h after injury corresponds to the first phase involving severe hypovolemic shock. The second phase corresponds to the hypermetabolic response to burns. Altered pharmacokinetics of anticonvulsant drugs is observed. Albumin and other plasma proteins are reduced, leading to increased free fraction of phenytoin, resulting in greater clearance and a lower total drug concentration. Associated with metabolic changes of burned patient, this fact predisposes to seizures in epileptic burned patients. The authors present the case of an epileptic 36-year-old-woman who developed recurrent seizures after a thermal injury, despite using the same medications and doses of anticonvulsant drugs of last 12 years, with controlled epilepsy.<p />  <p>Language: en</p>
LA  - en
SN  - 0305-4179
UR  - http://dx.doi.org/10.1016/j.burns.2014.08.004
ID  - ref1
ER  -