TY  - JOUR
PY  - 2014//
TI  - Spinal cord injury induces a long-lasting upregulation of interleukin-1β in astrocytes around the central canal
JO  - Neuroscience
A1  - Paniagua-Torija, B.
A1  - Arevalo-Martin, A.
A1  - Molina-Holgado, E.
A1  - Molina-Holgado, F.
A1  - Garcia-Ovejero, D.
SP  - 283
EP  - 289
VL  - 284C
IS  - 
N2  - Under inflammatory conditions, interleukin-1β (IL-1β) modulates neural stem cells at neurogenic niches. Here we show that spinal cord injury in rats increases IL-1β expression in astrocytes located around the spinal cord ependyma, a region that also holds a neurogenic potential. IL-1β increases from day 1 after lesion, reaches maximal levels between days 3 and 7, and declines from 14days to low levels after 28days. At the time of maximal expression, periependymal upregulation of IL-1β extends beyond 5mm from the epicenter of the lesion both rostral and caudally. Since IL-1β controls proliferation and cell fate of neural stem/precursor cells, its modulation in periependymal astrocytes might create an appropriate environment for cell replacement after injury.<p /> <p>Language: en</p>
LA  - en
SN  - 0306-4522
UR  - http://dx.doi.org/10.1016/j.neuroscience.2014.10.013
ID  - ref1
ER  -